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5'-O-(4,4'-Dimethoxytrityl)thymidine is used in the solid-phase synthesis of polynucleotides and polythymidylic acids by the block coupling phosphotriester method. Further, it is used in the stereoselective synthesis of 3'-deoxy-3'-threo-hydroxymethyl nucleoside. In addition to this, it is used as a research tool for antiviral and anticancer studies.
Sontakke, V. A.; Shinde, V. S.; Lönnberg, H.; Ora, M. Synthesis and Stability of Nucleoside 3',5'-Cyclic Phosphate Triesters Masked with Enzymatically and Thermally Labile Phosphate Protecting Groups. Eur. J. Org. Chem. 2015, 2015 (2), 389-394.
Gimenez Molina, A.; Jabgunde, A. M.; Virta, P.; Lonnberg, H. Assembly of Short Oligoribonucleotides from Commercially Available Building Blocks on a Tetrapodal Soluble Support. Curr. Org. Synth. 2015, 12 (2), 202-207.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.