I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Osmium(VIII) oxide is widely used as an oxidant in organic synthesis to oxidize alkenes to vicinal diols as well as in the sharpless oxyamination to give vicinal amino-alcohols. It is involved in the oxidative cleavage of alkenes (Lemieux-Johnson oxidation) in association with sodium periodate. It finds application in transmission electron microscopy (TEM) as a staining agent. It is involved in the promotion of oxidative cleavage of graphene layers in carbon nanotubes and as an intermediate in osmium ore refining. As a lipid stain, it is useful in scanning electron microscopy (SEM) as an alternative to sputter coating.
Jacobsen, M.; Flechsig, G. U. Hybridization Detection of Osmium Tetroxide Bipyridine-Labeled DNA and RNA on Heated Gold Wire Electrodes. Electroanalysis 2013, 25 (2), 373-379.
Hart, S. R.; Whitehead, D. C.; Travis, B. R.; Borhan, B. Catalytic oxidative cleavage of olefins promoted by osmium tetroxide and hydrogen peroxide. Org. Biomol. Chem. 2011, 9 (13), 4741-4744.
Hazard Statements: H310-H315-H318-H332-H334
Fatal in contact with skin. Causes skin irritation. Causes serious eye damage. Harmful if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statements: P261-P262-P264b-P270-P271-P280-P285-P302+P350-P304+P340-P305+P351+P338-P310-P332+P313-P342+P311-P361-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. In case of inadequate ventilation wear respiratory protection. IF ON SKIN: Gently wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. If skin irritation occurs: Get medical advice/attention. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant