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Phenyllithium is used as an alkylating agent to facilitate the formation of carbon-carbon bonds by nucleophilic addition and substitution reactions. It is used in the preparation of 2-phenylpyridine by reacting with pyridine. It acts as a metalating agent in organic syntheses and a substitute for Grignard reagents for introducing phenyl groups in organic synthesis.
Bohler, B.; Gunther, H. The Aggregation Behavior of Butyllithium in Diethyl Ether in the Presence of LiBr, LiClO4, and Phenyllithium: A Deuterium-Induced Secondary 6Li-NMR Isotope-Effect Study. Helv. Chim. Acta 2015, 98 (4), 427-446.
Kojima, T.; Hiraoka, S. Mesityllithium and p-(dimethylamino) phenyllithium for the selective alternate trilithiation of the hexaphenylbenzene framework. Chem. Commun. 2014, 50 (72), 10420-10423.
Hazard Statements: H226-H303-H314-H318-H340-H350-H335
Flammable liquid and vapour. May be harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. May cause genetic defects. May cause cancer. May cause respiratory irritation.
Precautionary Statements: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.