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Polyvinylpyrrolidone-iodine complex is used as a slow iodine release formulation that iodinates lipids and oxidizes cell compounds such as tyrosine side chains. It is utilized to study microbial decontamination of human donor eyes as well as inactivation of infectious hematopoietic necrosis virus. It is also used as a carbon nanotube coating agent to enhance water solubility. It serves as a topical antiseptic in surgery, as an aerosol for skin and mucous membrane infections and is used to prevent infection in wounds.
Zhao, Y.; Yan, J.; Xia, Y.; Zhang, F.; Gu, N. Enhanced Osteogenesis of Polyvinylpyrrolidone-Iodine as a Sterilizing Agent for Preservation of Allografts. J Biomater Tissue Eng 2015, 5 (6), 465-471.
Jiang, Y.; Chen, L.; Zhang, S.; Tong, T.; Zhang, W.; Liu, W.; Xu, G.; Tuan, R. S.; Heng, B. C.; Crawford, R.; Xiao, Y.; Ouyang, H. W. Incorporation of bioactive polyvinylpyrrolidone-iodine within bilayered collagen scaffolds enhances the differentiation and subchondral osteogenesis of mesenchymal stem cells. Acta Biomater. 2013, 9 (9), 8089-8098.