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Diaion® HP21, synthetic adsorbent resin, is used in amino acid separations, small molecules in medium hydrophobicity in polar solvents. It is also widely used in refining of pharmaceuticals and natural extracts. They are used in a variety of industrial applications, especially adsorption, desalting and decolorization of natural products and small proteins. Some of the other applications include Polypeptide and proteins refining, Natural extracts refining, e.g. polyphenols, Preparation of fermentation, Chromatographic separation.