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Polyoxyethylene bis(amine) with HCl, it act as reduction agent; stereo selective allylation of carbonyl compounds; in situ generation of tinenolates for directed aldol reactions. It is used in the preparation of enzyme conjugates, promising drug carrier.
Robert J Lee; Philip S Low. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1995, 1233 (2), 134-144.
Wenjin Guo, Robert J. Lee. Receptor-targeted gene delivery viafolate-conjugated polyethylenimine. AAPS PharmSci. 1999, 1 (4), 20-26.