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Diphenylphosphine acts as an intermediate in the preparation of diphenylphosphide derivatives, phosphonium salts, phosphine ligands and Wittig-Horner reagents. The presence of hydrogen atom bonded to phosphorus undergoes Michael-like addition to activated alkenes. It is involved in the preparation of 1,2-bis(diphenylphosphino)ethane and (phenyl-(phenylmethyl)phosphoryl)benzene. Further, it is used in the synthesis of aminophosphines and chiral palladacycles with N-heterocyclic carbene ligands as catalysts.
Maser, L.; Flosdorf, K.; Langer, R. Synthesis and Reactivity of Iron(II) Hydride Complexes Containing Diphenylphosphine Ligands. J. Organomet. Chem. 2015, 791, 6-12.
Chew, R. J.; Li, X. R.; Li, Y.; Pullarkat, S. A.; Leung, P. H. Pd-Catalyzed Enantiodivergent and Regiospecific phospha-Michael Addition of Diphenylphosphine to 4-oxo-Enamides: Efficient Access to Chiral Phosphinocarboxamides and Their Analogues. Chem. Eur. J. 2015, 21 (12), 4800-4804.
Hazard Statements: H250-H252-H315-H319-H335
Catches fire spontaneously if exposed to air. Self-heating in large quantities; may catch fire. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P222-P305+P351+P338-P405-P422a-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not allow contact with air. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Store contents under inert gas. Dispose of contents/container in accordance with local/regional/national/international regulations.