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Inhibitor of protein tyrosine phosphatase and alkaline phosphate Sodium orthovanadate is used in protein analysis in molecular biology and acts as an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and kinases. It is also used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase. It serves as a reagent in the development of matrix Chip that utilizes surface-immobilized antibodies. Further, it is utilized for the preservation of protein tyrosyl phosphorylation state in cells and cell lysates.
Kumar, P.; Taha, A.; Kumar, N.; Kumar, V.; Baquer, N. Z. Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats. Prague Med Rep 2015, 116 (2), 122-138.
Korbecki, J.; Baranowska-Bosiacka, I.; Gutowska, I.; Piotrowska, K.; Chlubek, D. Cyclooxygenase-1 as the Main Source of Proinflammatory Factors After Sodium Orthovanadate Treatment. Biol. Trace Elem. Res. 2015, 163 (1-2), 103-111.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant