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Inhibitor of protein tyrosine phosphatase and alkaline phosphate Sodium orthovanadate is used in protein analysis in molecular biology and acts as an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and kinases. It is also used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase. It serves as a reagent in the development of matrix Chip that utilizes surface-immobilized antibodies. Further, it is utilized for the preservation of protein tyrosyl phosphorylation state in cells and cell lysates.
Kumar, P.; Taha, A.; Kumar, N.; Kumar, V.; Baquer, N. Z. Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats. Prague Med Rep 2015, 116 (2), 122-138.
Korbecki, J.; Baranowska-Bosiacka, I.; Gutowska, I.; Piotrowska, K.; Chlubek, D. Cyclooxygenase-1 as the Main Source of Proinflammatory Factors After Sodium Orthovanadate Treatment. Biol. Trace Elem. Res. 2015, 163 (1-2), 103-111.
Hazard Statements: H302-H332-H315-H319-H335
Harmful if swallowed. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280h-P305+P351+P338
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.