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Sulfuryl chloride is used as a chlorinating, sulfonating and chlorosulfonating agent. It is also used as a source of chlorine and acts as a reagent in the conversion of C-hydrogen to C-chlorine adjacent to activating substituent namely carbonyls and sulfoxides. As a chlorinating agent, it is involved in the chlorination of substrates like alkanes, alkenes, alkynes, aromatics, tetrahydrofuran and epoxides. It finds application in the conversion of thiols or disulfides into their corresponding sulfenyl chlorides. It plays a vital role to treat wool to prevent shrinkage.
Tanoue, A.; Yoo, W. J.; Kobayashi, S. Sulfuryl Chloride as an Efficient Initiator for the Metal-Free Aerobic Cross-Dehydrogenative Coupling Reaction of Tertiary Amines. Org. Lett. 2014, 16 (9), 2346-2349.
Boyd, D. R.; Sharma, N. D.; Kaik, M.; McIntyre, P. B.; Malone, J. F.; Stevenson, P. J. Reactions of enantiopure cyclic diols with sulfuryl chloride. Org Biomol Chem 2014, 12 (13), 2128-2136.
Hazard Statements: H314-H330-H335
Causes severe skin burns and eye damage. Fatal if inhaled. May cause respiratory irritation.
Precautionary Statements: P260-P264b-P271-P280-P284-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant