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Sulfuryl chloride is used as a chlorinating, sulfonating and chlorosulfonating agent. It is also used as a source of chlorine and acts as a reagent in the conversion of C-hydrogen to C-chlorine adjacent to activating substituent namely carbonyls and sulfoxides. As a chlorinating agent, it is involved in the chlorination of substrates like alkanes, alkenes, alkynes, aromatics, tetrahydrofuran and epoxides. It finds application in the conversion of thiols or disulfides into their corresponding sulfenyl chlorides. It plays a vital role to treat wool to prevent shrinkage.
Tanoue, A.; Yoo, W. J.; Kobayashi, S. Sulfuryl Chloride as an Efficient Initiator for the Metal-Free Aerobic Cross-Dehydrogenative Coupling Reaction of Tertiary Amines. Org. Lett. 2014, 16 (9), 2346-2349.
Boyd, D. R.; Sharma, N. D.; Kaik, M.; McIntyre, P. B.; Malone, J. F.; Stevenson, P. J. Reactions of enantiopure cyclic diols with sulfuryl chloride. Org Biomol Chem 2014, 12 (13), 2128-2136.
Hazard Statements: H314-H335
Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.