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14508-49-7 - 2-Chloropyrazine, 98% - A10108 - Alfa Aesar

A10108 2-Chloropyrazine, 98%

CAS Number
14508-49-7
Synonyms

Size Price ($) Quantity Availability
5g 44.46
25g 148.66
100g 433.60
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2-Chloropyrazine, 98%

MDL
MFCD00006124
EINECS
238-517-0

Chemical Properties

Formula
C4H3ClN2
Formula Weight
114.54
Boiling Point
153-154°
Flash Point
57°(134°F)
Density
1.284
Refractive Index
1.5370
Solubility
Soluble in Methanol

Applications

2-Chloropyrazine is used in cardiotonic, in biological, drug, flavoring and perfumery industry.

Notes

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Literature References

C Gosmini; JY Nédélec; J Périchon. Electrochemical cross-coupling between functionalized aryl halides and 2-chloropyrimidine or 2-chloropyrazine catalyzed by nickel 2, 2?-bipyridine complex. Tetrahedron Letters. 2000, 41, (2), 201-203.

JM Bégouin, C Gosmini. Cobalt-catalyzed cross-coupling between in situ prepared arylzinc halides and 2-chloropyrimidine or 2-chloropyrazine. The Journal of organic chemistry. 2009, 74, (8), 3221-3224.

The activated chlorine is readily displaced by nucleophiles. In an interesting synthesis of a fused pyridine, intramolecular cycloaddition is followed by elimination of HCN via a retro-Diels-Alder reaction: Tetrahedron, 44, 2977 (1988):

Selectively metallated at the 3-position by LDA or Li tetramethylpiperidide. The lithio-derivative reacts with electrophiles in good yield: Synthesis, 881 (1988).

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
107019
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
Yes

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