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2-Chloropyrazine is used in cardiotonic, in biological, drug, flavoring and perfumery industry.
C Gosmini; JY Nédélec; J Périchon. Electrochemical cross-coupling between functionalized aryl halides and 2-chloropyrimidine or 2-chloropyrazine catalyzed by nickel 2, 2?-bipyridine complex. Tetrahedron Letters. 2000, 41, (2), 201-203.
JM Bégouin, C Gosmini. Cobalt-catalyzed cross-coupling between in situ prepared arylzinc halides and 2-chloropyrimidine or 2-chloropyrazine. The Journal of organic chemistry. 2009, 74, (8), 3221-3224.
The activated chlorine is readily displaced by nucleophiles. In an interesting synthesis of a fused pyridine, intramolecular cycloaddition is followed by elimination of HCN via a retro-Diels-Alder reaction: Tetrahedron, 44, 2977 (1988):
Selectively metallated at the 3-position by LDA or Li tetramethylpiperidide. The lithio-derivative reacts with electrophiles in good yield: Synthesis, 881 (1988).
Hazard Statements: H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant