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147-24-0 - Diphenhydramine hydrochloride, 99% - A10136 - Alfa Aesar

A10136 Diphenhydramine hydrochloride, 99%

CAS Number
147-24-0
Synonyms

Size Price ($) Quantity Availability
50g 27.19
250g 85.18
1000g 293.55
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Diphenhydramine hydrochloride, 99%

MDL
MFCD00012479
EINECS
205-687-2

Chemical Properties

Formula
(C6H5)2CHOCH2CH2N(CH3)2•HCl
Formula Weight
291.82
Melting point
168-169°
Sensitivity
Light Sensitive
Solubility
Soluble in water, dimethyl sulfoxide, dimethylformamide, methanol and ethanol.

Applications

A histamine H1 receptor antagonistDiphenhydramine hydrochloride acts as a sodium channel blocker. It is used as a histamine H1-receptor antagonist. Further, it is used as a sedative, hypnotic, antiemetic, antitussive and pruritus. It is employed in the treatment of allergic conditions. In addition to this, it is used as an active ingredient in common cold preparations.

Notes

Incompatible with strong oxidizing agents, strong acids and alkalis.

Literature References

Miao, C.; Zhang, A.; Xu, Y.; Chen, S.; Ma, F.; Huang, C.; Jia, N. An ultrasensitive electrochemiluminescence sensor for detecting diphenhydramine hydrochloride based on l-cysteine-functionalized multiwalled carbon nanotubes/gold nanoparticles nanocomposites. Sens. Actuators, B 2015, 213, 5-11.

Jengathe, S. P.; Dhondge, S. S.; Paliwal, L. J.; Tangde, V. M.; Mondal, S. Effect of sodium chloride and myo-inositol on diphenhydramine hydrochloride drug in aqueous solution at different temperatures: Volumetric and acoustic approach. J. Chem. Thermodyn. 2015, 87, 78-87.

GHS Hazard and Precautionary Statements

Hazard Statements: H351-H361-H302-H315-H319-H335

Suspected of causing cancer. Suspected of damaging fertility or the unborn child. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P201-P261-P280-P281-P305+P351+P338-P304+P340-P362-P301+P312-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2922.19
TSCA
No

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