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A10181 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate, 98%

CAS Number
6001-64-5
Synonyms
Acetone chloroform
Chloretone

Stock No. Size Price ($) Quantity Availability
A10181-14 25g 27.30
A10181-22 100g 80.10
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1,1,1-Trichloro-2-methyl-2-propanol hemihydrate, 98%

MDL
MFCD00004461
EINECS
200-317-6

Chemical Properties

Formula
C4H7Cl3O•0.5H2O
Formula Weight
186.47 (177.46anhy)
Melting point
98-100°(anhy)
Boiling Point
167°
Flash Point
>100°(212°F)
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in ethanol, ether, chloroform, and glycerol. Insoluble in water.

Applications

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate converts benzisoxazole to α-aryloxyisobutyric acid. It forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.

Notes

Incompatible with oxidizing agents. Store in a cool, dry condition in well sealed containers.

Literature References

Małgorzata Jaworska; Zofia Szulińska; Małgorzata Wilk. Application of a capillary electrophoresis method for simultaneous determination of preservatives in pharmaceutical formulations. Journal of Separation Science. 2005, 28 (2), 137-143.

M S Tesconi; K Sepassi; S H Yalkowsky. Freeze-drying above room temperature. Journal of Pharmaceutical Sciences. 1999, 88 (5), 501-506.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2129
Beilstein
878167
Harmonized Tariff Code
2905.59
TSCA
Yes
RTECS
UC0175000

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