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1,1,1-Trichloro-2-methyl-2-propanol hemihydrate converts benzisoxazole to α-aryloxyisobutyric acid. It forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.
Małgorzata Jaworska; Zofia Szulińska; Małgorzata Wilk. Application of a capillary electrophoresis method for simultaneous determination of preservatives in pharmaceutical formulations. Journal of Separation Science. 2005, 28 (2), 137-143.
M S Tesconi; K Sepassi; S H Yalkowsky. Freeze-drying above room temperature. Journal of Pharmaceutical Sciences. 1999, 88 (5), 501-506.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.