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D-Alanine is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls.
Kazuo Izaki; Michio Matsuhashi; and Jack L. Strominger. Biosynthesis of the Peptidoglycan of Bacterial Cell Walls XIII. Peptidoglycan Transpeptidase And D-Alanine Carboxypeptidase: Penicillin-Sensitive Enzymatic Reaction In Strains Of Escherichia Coli. The Journal of Biological Chemistry. 1968, 243,3180-3192.
Timothy D. H. Bugg; Sylvie Dutka-Malen; Michel Arthur; Patrice Courvalin; Christopher T. Walsh. Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity. Biochemistry. 1991, 30,(8), 2017-2021.