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2-Ketoglutaric acid is used as an intermediate in the krebs cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. It is also used in dietary supplements to improve protein synthesis.
T. Garcia-Rodriguez; A.M. GuTierrez-Navarro; R. Garcia; J.Perez Silva. Indole acetic acid production by Rhizobium: Effect of 2-ketoglutaric acid. Soil Biol. Biochem. 1982, 14,(2), 153-155.
F. Rocchiccioli; J. P. Leroux; and P. H. Cartier. Microdetermination of 2-ketoglutaric acid in plasma and cerebrospinal fluid by capillary gas chromatography mass spectrometry; application to pediatrics. Biological Mass Spectrometry. 1984, 11,(1), 24-28.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.