Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

A10280 Diisopropylamine, 99+%

CAS Number
108-18-9
Synonyms

Stock No. Size Price ($) Quantity Availability
A10280-AP 500ml 27.20
A10280-0F 2500ml 85.20
Add to Cart Bulk/Specialty Print Quote View Item

Diisopropylamine, 99+%

MDL
MFCD00008862
EINECS
203-558-5

Chemical Properties

Formula
[(CH3)2CH]2NH
Formula Weight
101.19
Melting point
-61°
Boiling Point
83-84°
Flash Point
-7°(19°F)
Density
0.718
Refractive Index
1.3920
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with water.

Applications

Diisopropylamine is used as a precursor to prepare lithium diisopropylamide and sulfenamides, which are used in rubber vulcanization. It is also involved in the synthesis of N,N-Diisopropylethylamine (Hünig's base) obtained by alkylation with diethyl sulfate. Diisopropylammonium bromide is a bromide salt of DIPA used as an inert alternative to barium titanate. It is widely used as solvent as well as an intermediate in the the synthesis of pharmaceuticals, dyes, mineral flotation agents and emulsifiers.

Notes

Air sensitive. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and plastics.

Literature References

Precursor of the sterically-hindered strong base lithium diisopropylamide (LDA), which has a greater "kinetic-basicity" than some thermodynamically stronger bases, e.g. alkyllithiums, and therefore finds wide application in lithiation reactions. LDA is a particularly useful base for the preparation of carboxylic acid dianions and ester enolates. For a review, see: Synthesis, 521 (1982).

LDA is generally prepared in situ by reaction of diisopropylamine with an alkyllithium; numerous examples in Org. Synth. Coll., 6, 7, 8, 9, and subsequent annual volumes. For discussion of methods for preparation, including Li metal in the presence of an aromatic hydrocarbon as electron-acceptor, see: Synthesis, 463 (1979); see also (Li in ether): Liebigs Ann. Chem., 1471 (1980).

LDA cleaves 1,3-dithiolanes (ethylene dithioacetals) to the carbonyl compounds: Synthesis, 1087 (1982):

1,3-Dithianes are not cleaved under these conditions.

Lee, A.; Lundberg, P.; Klinger, D.; Lee, B. F.; Hawker, C. J.; Lynd, N. A. Physiologically relevant, pH-responsive PEG-based block and statistical copolymers with N,N-diisopropylamine units. Polym. Chem. 2013, 4 (24), 5735-5742.

Mei, L.; Peng, H. Y.; Song, S. Y.; Sun, Y. H.; Liu, Q. T.; Zhang, K.; Shi, Y. G. Study on the Nano Material Produced by Diisopropylamine or N Butyl Alcohol as Exchange Solvent. Adv. Mater. Res. 2012, 610-613, 530-533.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H302-H314-H331-H335

Highly flammable liquid and vapour. Harmful if swallowed. Causes severe skin burns and eye damage. Toxic if inhaled. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3196
Beilstein
605284
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2921.19
TSCA
Yes
RTECS
IM4025000

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware