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Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.
Zhang, H, et al. Mass spectrometry-based carboxyl footprinting of proteins: method evaluation.Int. J. Mass Spectrom.,2012,31278-86.
Bill Morandi, et al. Iron-Catalyzed Cyclopropanation with Glycine Ethyl Ester Hydrochloride in Water.Org. Lett.,2012,14(8), 2162-2163.
Reacts with ß-diketones to give substituted pyrrole-2-carboxylic esters: Synthesis, 157 (1982):