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623-33-6 - Glycine ethyl ester hydrochloride, 99% - Ethyl glycinate hydrochloride - H-Gly-OEt.HCl - A10315 - Alfa Aesar

A10315 Glycine ethyl ester hydrochloride, 99%

CAS Number
623-33-6
Synonyms
Ethyl glycinate hydrochloride
H-Gly-OEt.HCl

Size Price ($) Quantity Availability
100g 22.45
500g 63.76
2500g 204.80
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Glycine ethyl ester hydrochloride, 99%

MDL
MFCD00012871
EINECS
210-787-4

Chemical Properties

Formula
CH3CH2O2CCH2NH2•HCl
Formula Weight
139.58
Melting point
144-148°
Sensitivity
Hygroscopic
Solubility
Soluble in water (>1000 mg/ml at 20°C), ethanol, DMSO, and methanol.

Applications

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.

Notes

Hygroscopic. Store away from oxidizing agents and water/moisture. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.

Literature References

Zhang, H, et al. Mass spectrometry-based carboxyl footprinting of proteins: method evaluation.Int. J. Mass Spectrom.,2012,31278-86.

Bill Morandi, et al. Iron-Catalyzed Cyclopropanation with Glycine Ethyl Ester Hydrochloride in Water.Org. Lett.,2012,14(8), 2162-2163.

Reacts with ß-diketones to give substituted pyrrole-2-carboxylic esters: Synthesis, 157 (1982):

GHS Hazard and Precautionary Statements

Hazard Statements: H318

Causes serious eye damage.

Precautionary Statements: P280-P305+P351+P338-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.

Other References

Beilstein
3594034
Harmonized Tariff Code
2922.49
TSCA
Yes
RTECS
MC0525000

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