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4-Methylumbelliferone is used in the determination of nitric acid and as a standard for fluorometric determination of enzyme activity. It is also used in bile therapy.
Standard for fluorimetric determination of enzyme activity: Anal. Biochem., 54, 40; 55, 85 (1973)./n
Franco, P. G.; Perez, M. J.; Aranda, C.; Adamo, A.; Silvestroff, L. Improving arylsulfatase activity determination in dried blood spots: Screening and diagnostic approaches for Maroteaux-Lamy syndrome (MPS VI). Clin. Chim. Acta 2015, 446, 86-92.
Kłucinska, K.; Jurczakowski, R.; Maksymiuk, K.; Michalska, A. Ultrasensitive 4-methylumbelliferone fluorimetric determination of water contents in aprotic solvents. Talanta 2015, 132, 392-397.
Hazard Statements: H315-H319-H335-H500
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May form combustible dust concentrations in air
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant