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3-Pyridinemethanol is a useful synthetic intermediate. Among other uses, it has been used in the synthesis of histone deacetylase inhibitors. It is also used to solubilize riboflavin and as a peripheral vasodilator; alcohol analog of nicotinic acid; a direct-acting peripheral vasodilator that is used in vasospasm and threatened gangrene.
Zane N. Gaut, et al. Effects of Large Doses of Nicotinyl Alcohol on Serum Lipid Levels and Carbohydrate Tolerance. The Journal of Clinical Pharmacology and The Journal of New Drugs.,1968,8(6), 370-376.
V. Arjunan, et al. A comparative study on vibrational, conformational and electronic structure of 2-(hydroxymethyl)pyridine and 3-(hydroxymethyl)pyridine.J. Mol. Struct.,2012,1018156-170.
3-Picolyl esters can be prepared by carbodiimide coupling and have been used for protection of the side chain carboxyl groups of aspartic and glutamic acids in peptide synthesis: J. Org. Chem., 53, 5386 (1988). See Appendix 6.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.