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3-Pyridinemethanol is a useful synthetic intermediate. Among other uses, it has been used in the synthesis of histone deacetylase inhibitors. It is also used to solubilize riboflavin and as a peripheral vasodilator; alcohol analog of nicotinic acid; a direct-acting peripheral vasodilator that is used in vasospasm and threatened gangrene.
Zane N. Gaut, et al. Effects of Large Doses of Nicotinyl Alcohol on Serum Lipid Levels and Carbohydrate Tolerance. The Journal of Clinical Pharmacology and The Journal of New Drugs.,1968,8(6), 370-376.
V. Arjunan, et al. A comparative study on vibrational, conformational and electronic structure of 2-(hydroxymethyl)pyridine and 3-(hydroxymethyl)pyridine.J. Mol. Struct.,2012,1018156-170.
3-Picolyl esters can be prepared by carbodiimide coupling and have been used for protection of the side chain carboxyl groups of aspartic and glutamic acids in peptide synthesis: J. Org. Chem., 53, 5386 (1988). See Appendix 6.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant