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Ninhydrin is used for the determination of amino groups in amino acids, peptides and proteins. It finds application in forensic science for the analysis of latent fingerprints on porous surfaces such as paper. It is also used in thin layer chromatography (TLC) to monitor the progress of chemical reactions. In Kaiser test, it plays an important role to monitor the deprotection in solid phase peptide synthesis.
Reagent for the detection and determination of peptides and amino acids.
Reviews: Chem. Rev., 60, 39 (1960); Tetrahedron, 34, 1285 (1978); 47, 8791 (1991).
Babu, K. R.; Khan, F. A. A domino reaction of tetrahalo-7, 7-dimethoxybicyclo [2.2. 1] heptenyl alcohols leading to indenones and a de novo synthesis of ninhydrin derivatives. Org. Biomol. Chem. 2015, 13 (1), 299-308.
Omar, M. A.; Hammad, M. A.; Nagy, D. M.; Aly, A. A. Development of spectrofluorimetric method for determination of certain aminoglycoside drugs in dosage forms and human plasma through condensation with ninhydrin and phenyl acetaldehyde. Spectrochim. Acta, Part A 2015, 136, 1760-1766.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant