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Ninhydrin is used for the determination of amino groups in amino acids, peptides and proteins. It finds application in forensic science for the analysis of latent fingerprints on porous surfaces such as paper. It is also used in thin layer chromatography (TLC) to monitor the progress of chemical reactions. In Kaiser test, it plays an important role to monitor the deprotection in solid phase peptide synthesis.
Reagent for the detection and determination of peptides and amino acids.
Reviews: Chem. Rev., 60, 39 (1960); Tetrahedron, 34, 1285 (1978); 47, 8791 (1991).
Babu, K. R.; Khan, F. A. A domino reaction of tetrahalo-7, 7-dimethoxybicyclo [2.2. 1] heptenyl alcohols leading to indenones and a de novo synthesis of ninhydrin derivatives. Org. Biomol. Chem. 2015, 13 (1), 299-308.
Omar, M. A.; Hammad, M. A.; Nagy, D. M.; Aly, A. A. Development of spectrofluorimetric method for determination of certain aminoglycoside drugs in dosage forms and human plasma through condensation with ninhydrin and phenyl acetaldehyde. Spectrochim. Acta, Part A 2015, 136, 1760-1766.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.