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A10439 4'-Hydroxy-3'-methoxyacetophenone, 98%

CAS Number
498-02-2
Synonyms
Acetovanillone
Apocynin

Stock No. Size Price ($) Quantity Availability
A10439-18 50g 31.60
A10439-30 250g 109.00
A10439-36 500g 186.00
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4'-Hydroxy-3'-methoxyacetophenone, 98%

MDL
MFCD00008747
EINECS
207-854-5

Chemical Properties

Formula
C9H10O3
Formula Weight
166.18
Melting point
112-116°
Boiling Point
295-300°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in ethanol, chloroform, ether, hot water, benzene, ethyl acetate and dimethyl sulfoxide. Insoluble in petroleum ether.

Applications

4'-Hydroxy-3'-methoxyacetophenone is used as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which is an enzyme responsible for reactive oxygen species production. It is also useful in the treatment of various inflammatory diseases and atherosclerosis. Further, it shows an anti-inflammatory activity and improves endothelial function by reducing oxidative stress. In addition to this, it is used for studying nitric oxide regulated processes in plants.

Notes

Incompatible with strong oxidizing agents.

Literature References

Harman-Ware, A. E.; Crocker, M.; Pace, R. B.; Placido, A.; Morton III, S.; DeBolt, S. Characterization of Endocarp Biomass and Extracted Lignin Using Pyrolysis and Spectroscopic Methods. Bioenergy Res. 2015, 8 (1), 350-368.

McKay, D. L.; Chen, C. Y. O.; Zampariello, C. A.; Blumberg, J. B. Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults. Food Chem. 2015, 168, 233-240.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,741
Beilstein
637373
Harmonized Tariff Code
2914.50
TSCA
Yes
RTECS
AM8800000

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