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A10448 Ethyl bromoacetate, 98%

CAS Number
105-36-2
Synonyms
Bromoacetic acid ethyl ester

Stock No. Size Price ($) Quantity Availability
A10448-22 100g 30.80
A10448-36 500g 89.60
A10448-0E 2500g 315.00
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Ethyl bromoacetate, 98%

MDL
MFCD00000191
EINECS
203-290-9

Chemical Properties

Formula
C4H7BrO2
Formula Weight
167.00
Melting point
-38°
Boiling Point
159°
Flash Point
47°(117°F)
Density
1.506
Refractive Index
1.4510
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water.

Applications

Ethyl bromoacetate is widely used as an alkylating reagent involved in the Reformatsky reaction to prepare the beta-hydroxy esters by reacting with carbonyl compounds. It is also used for the syntheses of witting reagent, artificial diethylstilbestrol antigen, 3-phenyl-1-naphthol and steroidal thiazolidinone derivatives. It finds applications in the preparation of reversibly photoresponsive coumarin-stabilized polymeric nanoparticles in an aqueous medium which act as a detectable drug carrier.

Notes

It is a lachrymator. Incompatible with strong oxidizing agents.

Literature References

Zhang, Y.; Zhao, K. T.; Fox, S. G.; Kim, J.; Kirsch, D. R.; Ferrante, R. J.; Silverman, R. B. Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. J. Med. Chem. 2015, 58 (15), 5942-5949.

Grzybowski, M., & Gryko, D. T. Diketopyrrolopyrroles: Synthesis, Reactivity, and Optical Properties. Adv. Opt. Mater. 2015, 3 (3), 280-320.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H300-H310-H330

Flammable liquid and vapour. Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P260-P262-P264b-P270-P271-P280-P284-P301+P310-P303+P361+P353-P304+P340-P310-P330-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
AF6000000

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