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105-36-2 - Ethyl bromoacetate, 98% - Bromoacetic acid ethyl ester - A10448 - Alfa Aesar

A10448 Ethyl bromoacetate, 98%

CAS Number
105-36-2
Synonyms
Bromoacetic acid ethyl ester

Size Price ($) Quantity Availability
100g 26.82
500g 85.28
2500g 286.79
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Ethyl bromoacetate, 98%

MDL
MFCD00000191
EINECS
203-290-9

Chemical Properties

Formula
C4H7BrO2
Formula Weight
167.00
Melting point
-38°
Boiling Point
159°
Flash Point
47°(117°F)
Density
1.506
Refractive Index
1.4510
Solubility
Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water.

Applications

Ethyl bromoacetate is widely used as an alkylating reagent involved in the Reformatsky reaction to prepare the beta-hydroxy esters by reacting with carbonyl compounds. It is also used for the syntheses of witting reagent, artificial diethylstilbestrol antigen, 3-phenyl-1-naphthol and steroidal thiazolidinone derivatives. It finds applications in the preparation of reversibly photoresponsive coumarin-stabilized polymeric nanoparticles in an aqueous medium which act as a detectable drug carrier.

Notes

It is a lachrymator. Incompatible with strong oxidizing agents.

Literature References

Zhang, Y.; Zhao, K. T.; Fox, S. G.; Kim, J.; Kirsch, D. R.; Ferrante, R. J.; Silverman, R. B. Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. J. Med. Chem. 2015, 58 (15), 5942-5949.

Grzybowski, M., & Gryko, D. T. Diketopyrrolopyrroles: Synthesis, Reactivity, and Optical Properties. Adv. Opt. Mater. 2015, 3 (3), 280-320.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H310-H330-H226

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Flammable liquid and vapour.

Precautionary Statements: P210-P260-P301+P310-P303+P361+P353-P304+P340-P320-P330-P361-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
AF6000000

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