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A10459 Quinine, anhydrous, 99% (total base), may cont. up to 5% dihydroquinine

CAS Number
130-95-0
Synonyms

Stock No. Size Price ($) Quantity Availability
A10459-09 10g 53.40
A10459-18 50g 176.00
A10459-30 250g 670.00
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Quinine, anhydrous, 99% (total base), may cont. up to 5% dihydroquinine

MDL
MFCD00198096
EINECS
205-003-2

Chemical Properties

Formula
C20H24N2O2
Formula Weight
324.42
Melting point
ca 177° dec.
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in alcohol, chloroform and diethyl ether. Slightly soluble in water and glycerol.

Applications

Quinine is used in photochemistry as a common fluorescence standard and as a resolving agent for chiral acids. It is also useful for treating falciparum malaria, lupus, arthritis and vivax malaria. It acts as a flavor component in tonic water and bitter lemon. It is utilized as the chiral moiety for the ligands used in sharpless asymmetric dihydroxylation. Furthermore, it catalyzes the kinetic resolution of furanones.

Notes

Incompatible with strong oxidizing agents.

Literature References

Porta, R.; Benaglia, M.; Coccia, F.; Rossi, S.; Puglisi, A. Enantioselective Organocatalysis in Microreactors: Continuous Flow Synthesis of a (S)-Pregabalin Precursor and (S)-Warfarin. Symmetry 2015, 7 (3), 1395-1409.

Porta, R.; Coccia, F.; Annunziata, R.; Puglisi, A. Comparison of Different Polymer-and Silica-Supported 9-Amino-9-deoxy-epi-quinines as Recyclable Organocatalysts. ChemCatChem 2015, 7 (9), 1490-1499.

Kessler, S.; González, J.; Vlimant, M.; Glauser, G.; Guerin, P. M. Quinine and artesunate inhibit feeding in the African malaria mosquito Anopheles gambiae: the role of gustatory organs within the mouthparts. Physiol. Entomol. 2014, 39 (2), 172-182.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H317

Harmful if swallowed. May cause an allergic skin reaction.

Precautionary Statements: P261-P264b-P270-P272-P280g-P285-P301+P312-P302+P352-P304+P341-P330-P333+P313-P342+P311-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,8061
Beilstein
91867
Harmonized Tariff Code
2939.20
TSCA
No
RTECS
VA6020000

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