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2216-51-5 - L-Menthol, 99% - (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol - A10474 - Alfa Aesar

A10474 L-Menthol, 99%

CAS Number
2216-51-5
Synonyms
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Size Price ($) Quantity Availability
50g 30.69
250g 64.79
1000g 230.72
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L-Menthol, 99%

MDL
MFCD00062979
EINECS
218-690-9

Chemical Properties

Formula
C10H20O
Formula Weight
156.27
Melting point
42-45°
Boiling Point
212-216°
Flash Point
93°(199°F)
Density
0.89
Solubility
Soluble in 100% ethanol, methanol (100 mg/ml), ether, and chloroform. Insoluble in water.

Applications

L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.

Notes

Store at -20°C. Incompatible with Strong oxidizing agents, phenols, potassium permanganate, chromium trioxide, chloral hydrate, thymol, pyrogallol, resorcinol, camphor, butylchloral hydrate, betanaphthol, exalgine.

Literature References

UR Juergens, M Stöber, H Vetter. The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases. European journal of medical research.1998, 3, (12) 539-545.

The L-menthyl ester of succinic acid has been used in a chiral synthesis of (1S,2S)-cyclopropanedicarboxylic acid: Org. Synth. Coll., 8, 141 (1993):

One recrystallization gives the pure enantiomer.

GHS Hazard and Precautionary Statements

Hazard Statements: H318-H315-H335-H303

Causes serious eye damage. Causes skin irritation. May cause respiratory irritation. May be harmful if swallowed.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P310-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5837
Beilstein
1902293
Harmonized Tariff Code
2906.11
TSCA
Yes
RTECS
OT0700000

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