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55-21-0 - Benzamide, 98+% - A10501 - Alfa Aesar

A10501 Benzamide, 98+%

CAS Number
55-21-0
Synonyms

Size Price ($) Quantity Availability
100g 26.06
500g 69.73
2500g 208.00
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Benzamide, 98+%

MDL
MFCD00007968
EINECS
200-227-7

Chemical Properties

Formula
C7H7NO
Formula Weight
121.14
Melting point
125-129°
Boiling Point
288°
Flash Point
180°(356°F)
Density
1.341
Solubility
Soluble in water, methanol, ammonia, pyridine, carbon tetrachloride, carbon disulfide and ethanol. Slightly soluble in benzene and ethyl ether.

Applications

Benzamide is utilized to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It is used as a nictoinamide-mimic PARP inhibitor and neuroprotectant. Further, it is used to develop a robust screening method to study biotransformations using (+)-gamma-lactamase enzyme. It is also employed in the determination of glycine. In addition to this, it is used as an intermediate in organic synthesis as well as in the production of pharmaceuticals and dyes.

Notes

Incompatible with strong oxidizing agents and strong bases.

Literature References

Reduction with lithium aluminum hydride gives benzylamine. By using lithium tris(diethylamino)aluminum hydride (see Diethyl­amine, A11716), selective reduction to benzaldehyde is possible: Tetrahedron Lett., 32, 6903 (1991).

An exceptionally mild method for dehydration of amides to nitriles by transamidation with acetonitrile in the presence of an aldehyde and formic acid is exemplified by the high yield conversion of benzamide to benzonitrile: J. Org. Chem., 61, 6486 (1996).

Barrett, K. T.; Miller, S. J. Regioselective Derivatizations of a Tribrominated Atropisomeric Benzamide Scaffold. Org. Lett. 2015, 17 (3), 580-583.

Manna, S.; Antonchick, A. P. Organocatalytic Oxidative Annulation of Benzamide Derivatives with Alkynes. Angew. Chem. Int. Ed. 2014, 53 (28), 7324-7327.

GHS Hazard and Precautionary Statements

Hazard Statements: H341-H302

Suspected of causing genetic defects. Harmful if swallowed.

Precautionary Statements: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1060
Beilstein
385876
Harmonized Tariff Code
2924.29
TSCA
Yes
RTECS
CU8700000

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