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7447-41-8 - Lithium chloride, anhydrous, 98+% - A10531 - Alfa Aesar

A10531 Lithium chloride, anhydrous, 98+%

CAS Number

Size Price ($) Quantity Availability
100g 27.90
500g 62.62
2500g 180.25
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Lithium chloride, anhydrous, 98+%


Chemical Properties

Formula Weight
Melting point
Boiling Point
Soluble in water methanol, ethanol, pyridine and formic acid. Insoluble in dichloromethane.


Lithium chloride is useful for the production of lithium metal and for the generation of Mn(0) species which can be used in free radical cyclizations. It can serve as a flame colorant to generate dark red flames, a brazing flux for aluminum in automobiles, a hygrometer and a desiccant for drying air streams. On exposure to air, it becomes a solution with the concentration directly related to relative humidity of the atmosphere and hence serves as a relative humidity standard in calibrating hygrometers. Apart from being a source of chloride, it serves as an additive in the Stille reaction in organic synthesis and to precipitate RNA from cellular extracts. Being biologically significant, it finds applications in a wide variety of assays to study cell-fate and neurobiology. Lithium chloride has been found to inhibit virus infection.


It is hygroscopic in nature. Incompatible with strong oxidizing agents, strong acids, bromine trichloride and bromine trifluoride. Deliquescent salt forms a solution when exposed to humid air. Store in a cool and dry place in closed tight containers.

Literature References

In DMF, acts as a base in dehydrohalogenation reactions; see, for example: Org. Synth. Coll., 4, 162 (1963). See also lithium carbonate (preceding entry). A comparison has been made of its activity with or without microwave irradiation for promoting the Knoevenagel condensation in N-methylpyrrolidinone, e.g. of malononitrile: Chem. Commun., 773 (1998).

For use in the dealkylation of activated aralkyl ethers, see: Synthesis, 287 (1989).

In the Wadsworth-Emmons olefination reaction, Triethyl­amine, A12646, was effective as base in combination a number of metal salts of which Li halides gave the highest yields: J. Org. Chem., 50, 2624 (1985).

Additive in the Stille coupling reaction of alkyl and arylstannanes with aryl triflates, preventing decomposition of the palladium complex catalyst: J. Am. Chem. Soc., 106, 4630 (1984); 108, 3033 (1986); see also Tri-n-butyl­tin chloride, A10746.

The combination of LiCl and water in DMSO provides a mild and efficient method for deprotection of THP ethers: J. Org. Chem., 61, 6038 (1996), and ethylene acetals: Tetrahedron Lett., 38, 7271 (1997).

Kowalczyk, S. W.; Wells, D. B.; Aksimentiev, A.; Dekker, C. Slowing down DNA Translocation through a Nanopore in Lithium Chloride. Nano Lett. 2012, 12 (2), 1038-1044.

Deng, L. J.; Liu, J.; Huang, J. Q.; Hud, Y.; Chen, M.; Lan, Y.; Chen, J. H.; Lei, A.; Yang, Z. Effect of Lithium Chloride on Tuning the Reactivity of Pauson-Khand Reactions Catalyzed by Palladium-Tetramethylthiourea. Synthesis 2007, 2565-2570.

Fumo, N.; Goswami, D. Y. Study of an Aqueous Lithium Chloride Desiccant System: Air Dehumidification and Desiccant Regeneration. Sol. Energy 2002, 72 (4), 51-361.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

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