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14470-28-1 - 4-Methoxytrityl chloride, 97% - p-Anisylchlorodiphenylmethane - 4-Methoxytriphenylmethyl chloride - A10545 - Alfa Aesar

A10545 4-Methoxytrityl chloride, 97%

CAS Number
14470-28-1
Synonyms
p-Anisylchlorodiphenylmethane
4-Methoxytriphenylmethyl chloride

Size Price ($) Quantity Availability
10g 35.43
50g 125.66
250g 450.40
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4-Methoxytrityl chloride, 97%

MDL
MFCD00000814
EINECS
238-463-8

Chemical Properties

Formula
C20H17ClO
Formula Weight
308.81
Melting point
121-125°
Sensitivity
Moisture Sensitive
Solubility
Soluble in toluene.

Applications

It is used as selective protecting reagent that is used for primary hydroxyl groups.

Notes

It is hygroscopic. Incompatible with oxidizing agents.

Literature References

Reagent for protection of alcohols, cf Chlorotriphenyl­methane, A11799, as their monomethoxytrityl (Mmt) ethers, intermediate in acid-lability between trityl (Trt) and dimethoxytrityl (Dmt); see 4,4'-Dimethoxytrityl­ chloride, A11626. For use of DMAP as a catalyst for methoxytritylation of alcohols and amines, see: Tetrahedron Lett., 21, 3899 (1980); J. Org. Chem., 47, 571 (1982); Chem. Lett., 15 (1982).

In a comparison with Dmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
798425
Harmonized Tariff Code
2909.30
TSCA
No

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