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A10545 4-Methoxytrityl chloride, 97%

CAS Number
14470-28-1
Synonyms
p-Anisylchlorodiphenylmethane
4-Methoxytriphenylmethyl chloride

Stock No. Size Price ($) Quantity Availability
A10545-09 10g 36.90
A10545-18 50g 130.00
A10545-30 250g 568.00
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4-Methoxytrityl chloride, 97%

MDL
MFCD00000814
EINECS
238-463-8

Chemical Properties

Formula
C20H17ClO
Formula Weight
308.81
Melting point
121-125°
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
Soluble in toluene.

Applications

It is used as selective protecting reagent that is used for primary hydroxyl groups.

Notes

It is hygroscopic. Incompatible with oxidizing agents.

Literature References

Reagent for protection of alcohols, cf Chlorotriphenyl­methane, A11799, as their monomethoxytrityl (Mmt) ethers, intermediate in acid-lability between trityl (Trt) and dimethoxytrityl (Dmt); see 4,4'-Dimethoxytrityl­ chloride, A11626. For use of DMAP as a catalyst for methoxytritylation of alcohols and amines, see: Tetrahedron Lett., 21, 3899 (1980); J. Org. Chem., 47, 571 (1982); Chem. Lett., 15 (1982).

In a comparison with Dmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
798425
Harmonized Tariff Code
2909.30
TSCA
No

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