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Bis(cyclohexanone) oxaldihydrazone is used in the quantitative spectroscopic determination of copper. It is also essential for the experimental study of mitochondrial metabolism. It is used to study the human demyelinating diseases such as multiple sclerosis and components of neuroinflammation. Further, it acts as ligand and catalyzes Ullmann-type C-N bond forming reactions in the presence of copper salt.
Reagent for spectrophotometric determination of Cu(II): Anal. Chem., 38, 911 (1966).
Krauspe, B. M.; Dreher, W.; Beyer, C.; Baumgartner, W.; Denecke, B.; Janssen, K.; Langhans, C. D.; Clarner, T.; Kipp, M. Short-Term Cuprizone Feeding VerifiesN-Acetylaspartate Quantification as a Marker of Neurodegeneration. J. Mol. Neurosci. 2015, 55 (3), 733-748.
Slowik, A.; Schmidt, T.; Beyer, C.; Amor, S.; Clarner, T.; Kipp, M. The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination. Br. J. Pharmacol. 2015, 172 (1), 80-92.