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370-81-0 - Bis(cyclohexanone) oxaldihydrazone, 98% - Oxalic acid bis(cyclohexylidenehydrazide) - Cuprizon I - A10628 - Alfa Aesar

A10628 Bis(cyclohexanone) oxaldihydrazone, 98%

CAS Number
370-81-0
Synonyms
Oxalic acid bis(cyclohexylidenehydrazide)
Cuprizon I

Size Price ($) Quantity Availability
25g 36.18
100g 111.34
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Bis(cyclohexanone) oxaldihydrazone, 98%

MDL
MFCD00001659
EINECS
206-729-2

Chemical Properties

Formula
C14H22N4O2
Formula Weight
278.36
Melting point
208-212°
Solubility
Soluble in alcohol. Insoluble in water.

Applications

Bis(cyclohexanone) oxaldihydrazone is used in the quantitative spectroscopic determination of copper. It is also essential for the experimental study of mitochondrial metabolism. It is used to study the human demyelinating diseases such as multiple sclerosis and components of neuroinflammation. Further, it acts as ligand and catalyzes Ullmann-type C-N bond forming reactions in the presence of copper salt.

Notes

Incompatible with strong oxidizing agents and strong bases.

Literature References

Reagent for spectrophotometric determination of Cu(II): Anal. Chem., 38, 911 (1966).

Krauspe, B. M.; Dreher, W.; Beyer, C.; Baumgartner, W.; Denecke, B.; Janssen, K.; Langhans, C. D.; Clarner, T.; Kipp, M. Short-Term Cuprizone Feeding VerifiesN-Acetylaspartate Quantification as a Marker of Neurodegeneration. J. Mol. Neurosci. 2015, 55 (3), 733-748.

Slowik, A.; Schmidt, T.; Beyer, C.; Amor, S.; Clarner, T.; Kipp, M. The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination. Br. J. Pharmacol. 2015, 172 (1), 80-92.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2388004
Harmonized Tariff Code
2928.00
TSCA
Yes
RTECS
RO2520000

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