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A10644 Methyl diethylphosphonoacetate, 97%

CAS Number
1067-74-9
Synonyms
Diethyl methoxycarbonylmethyl phosphonate
Phosphonoacetic acid diethyl methyl ester

Stock No. Size Price ($) Quantity Availability
A10644-14 25g 89.80
A10644-22 100g 247.00
A10644-36 500g 961.00
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Methyl diethylphosphonoacetate, 97%

MDL
MFCD00009081
EINECS
213-938-2

Chemical Properties

Formula
C7H15O5P
Formula Weight
210.17
Boiling Point
126-128°/8mm
Flash Point
>110°(230°F)
Density
1.145
Refractive Index
1.4320
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with tetrahydrofuran.

Applications

Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.

Notes

Incompatible with strong oxidizing agents.

Literature References

Zeller, W. E.; Schatz, P. F. Synthesis of monomethyl 5,5'-dehydrodiferulic acid. Tetrahedron Lett. 2015, 56 (9), 1076-1079.

Singh, R.; Reynolds, K. A. Characterization of FabG and FabI of the Streptomyces coelicolor Dissociated Fatty Acid Synthase. ChemBioChem 2015, 16 (4), 631-640.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1782397
Harmonized Tariff Code
2931.39
TSCA
No

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