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6148-64-7 - Ethyl potassium malonate, 98% - Malonic acid monoethyl ester potassium salt - Monoethyl malonate potassium salt - A10720 - Alfa Aesar

A10720 Ethyl potassium malonate, 98%

CAS Number
Malonic acid monoethyl ester potassium salt
Monoethyl malonate potassium salt

Size Price ($) Quantity Availability
25g 50.60
100g 165.00
500g 716.00
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Ethyl potassium malonate, 98%


Chemical Properties

Formula Weight
Melting point
ca 200° dec.
Soluble in water.


Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation. Further, it reacts with aryl nitriles to prepare beta-amino acrylates in the presence of zinc chloride and a catalytic amount of Hünig's base. In addition to this, it serves as an intermediate for the preparation of ethyl tert-butyl malonate.


Hygroscopic. Incompatible with strong oxidizing agents.

Literature References

An improved method for acylation with acid chlorides utilizes the Rathke MgCl2-triethylamine reagent in acetonitrile or ethyl acetate to give ß-keto esters in very high yields: Synthesis, 290 (1993):

Compare Diethyl­ malonate, A15468 and Dimethyl­ malonate, A11007, for other applications of this technique. See also Ethyl­ hydrogen malonate, A12627.

Alternatively, ß-keto esters can be obtained in high yield by reaction with TMS chloride to generate ethyl trimethylsilyl malonate, followed by in situ reaction with acyl imidazoles or acyl chlorides in the presence of DBU: Tetrahedron Lett., 35, 9323 (1994).

Tancock, J.; Wirth, T. Selenium-Mediated Synthesis of Tetrasubstituted Naphthalenes through Rearrangement. Molecules 2015, 20 (6), 10866-10872.

Stasyuk, A. J.; Smoleń, S.; Glodkowska-Mrowka, E.; Brutkowski, W.; Cyrański, M. K.; Tkachenko, N.; Gryko, D. T. Synthesis of Fluorescent Naphthoquinolizines via Intramolecular Houben-Hoesch Reaction. Chem. Asian J. 2015, 10 (3), 553-558.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


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