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A10727 Sulfathiazole, 99%

CAS Number
72-14-0
Synonyms
N(1)-(2-Thiazolyl)sulfanilamide

Stock No. Size Price ($) Quantity Availability
A10727-22 100g 45.40
A10727-36 500g 129.00
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Sulfathiazole, 99%

MDL
MFCD00005319
EINECS
200-771-5

Chemical Properties

Formula
C9H9N3O2S2
Formula Weight
255.32
Melting point
200-203°
Storage & Sensitivity
Ambient temperatures.
Solubility
Slightly soluble in water, deuterated dimethyl sulfoxide and ethanol. Soluble in acetone, dilute mineral acids, potassium hydroxide solution, sodium hydroxide solution, ammonia water, dimethyl sulphoxide and methanol.

Applications

Blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase and it inhibits folic acid synthesis in prokaryotes.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Literature References

A. P. Simonelli.; S. C. Mehta.; W. I. Higuchi. Dissolution rates of high energy sulfathiazole-povidone coprecipitates II: Characterization of form of drug controlling its dissolution rate via solubility studies. Journal of Pharmaceutical Sciences. 1976, 65, (3), 355-361.

Keiji Sekiguchi.; Noboru Obi. Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man. Chemical and Pharmaceutical Bulletin. 1961, 9 (11), 866-872.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,8943
Harmonized Tariff Code
2935.90
TSCA
Yes

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