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72-14-0 - Sulfathiazole, 99% - N(1)-(2-Thiazolyl)sulfanilamide - A10727 - Alfa Aesar

A10727 Sulfathiazole, 99%

CAS Number
72-14-0
Synonyms
N(1)-(2-Thiazolyl)sulfanilamide

Size Price ($) Quantity Availability
100g 45.29
500g 99.20
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Sulfathiazole, 99%

MDL
MFCD00005319
EINECS
200-771-5

Chemical Properties

Formula
C9H9N3O2S2
Formula Weight
255.32
Melting point
200-203°
Solubility
Slightly soluble in water, deuterated dimethyl sulfoxide and ethanol. Soluble in acetone, dilute mineral acids, potassium hydroxide solution, sodium hydroxide solution, ammonia water, dimethyl sulphoxide and methanol.

Applications

Blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase and it inhibits folic acid synthesis in prokaryotes.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Literature References

A. P. Simonelli.; S. C. Mehta.; W. I. Higuchi. Dissolution rates of high energy sulfathiazole-povidone coprecipitates II: Characterization of form of drug controlling its dissolution rate via solubility studies. Journal of Pharmaceutical Sciences. 1976, 65, (3), 355-361.

Keiji Sekiguchi.; Noboru Obi. Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man. Chemical and Pharmaceutical Bulletin. 1961, 9 (11), 866-872.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,8943
Harmonized Tariff Code
2934.10
TSCA
Yes

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