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127-07-1 - Hydroxyurea, 98% - A10831 - Alfa Aesar

A10831 Hydroxyurea, 98%

CAS Number
127-07-1
Synonyms

Size Price ($) Quantity Availability
1g 21.41
5g 78.76
25g 264.71
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Hydroxyurea, 98%

MDL
MFCD00007943
EINECS
204-821-7

Chemical Properties

Formula
CH4N2O2
Formula Weight
76.06
Melting point
ca 140° dec.
Solubility
Soluble in water, hot alcohol and dimethyl sulfoxide. Insoluble in ethanol and benzene.

Applications

Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS.

Notes

Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Literature References

Sheehan, V. A.; Nelson, S.; Yappan, C.; Dinu, B. R.; Guffey, D.; Minard, C. G.; Ware, R. E. Hydroxyurea Improves Oxygen Transport Effectiveness in Sickle Cell Anemia Patients. Blood 2014, 121 (24), 2716-2716.

Anele, U. A.; Mack, A. K.; Resar, L. M.; Burnett, A. L. Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease: a case report and review of the literature. Int Urol Nephrol 2014, 46 (9), 1733-1736.

GHS Hazard and Precautionary Statements

Hazard Statements: H340-H360

May cause genetic defects. May damage fertility or the unborn child.

Precautionary Statements: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4848
Beilstein
1741548
Harmonized Tariff Code
2928.00
TSCA
No
RTECS
YT4900000

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