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A10871 Pyridine hydrochloride, 98%

CAS Number
Pyridinium chloride

Stock No. Size Price ($) Quantity Availability
A10871-18 50g 22.00
A10871-30 250g 67.80
A10871-0B 1000g 244.00
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Pyridine hydrochloride, 98%


Chemical Properties

Formula Weight
Melting point
ca 145°
Boiling Point
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Soluble in water (85 g/100 ml) and methanol.


Pyridine hydrochloride is a classical reagent for cleavage of aryl methyl ethers at 200-220o. It is also used in the demethylation of 4,5-dimethyl-7-methoxy-1-tetralone.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. It is hygroscopic in nature.

Literature References

William G. Dauben.; Gerhard J. Fonken. Trofimov. Isomerization of Isospirostans to Furostenols with Pyridine Hydrochloride as the Catalyst. J. Am. Chem. Soc. 1954, 76, (18), 4618-4619.

T. S. Hamilton.; Roger Adams. Reduction Of Pyridine Hydrochloride And Pyridonium Salts By Means Of Hydrogen And Platinum-Oxide Platinum Black. XVIII1. J. Am. Chem. Soc. 1928, 50, (8), 2260-2263.

Classical reagent for cleavage of aryl methyl ethers at 200-220 o : Ber ., 75, 445 (1942), avoiding the strongly acidic or basic conditions of some alternative methods; see, e.g.: J. Org. Chem., 27, 4660 (1962):

Demethylation of methyl aryl ethers can also be carried out under solvent-free conditions with microwave irradiation: J. Chem. Res. (Synop.), 394 (1999).

Epoxides at ambient temperature in chloroform give chlorohydrins: Synth. Commun., 11, 287 (1981).

In DMF, has been used for the conversion of alkyl tosylates to chlorides at room temperature: J. Am. Chem. Soc., 80, 2726 (1958).

Cleaves N-trityl groups from histidine residues in peptide synthesis: Tetrahedron Lett., 28, 6031 (1987).

Mild acid catalyst, e.g. in the formation of acetals with ethylene glycol: J. Org. Chem., 31, 26 (1966), or 1,3-propanediol: Bull. Soc. Chim. Fr., 2287 (1972); and in the Fischer indole synthesis for acid-sensitive substrates: Synthesis, 645 (1977).

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H332-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


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    p-Anisidine, 99%
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    Magnesium, turnings, 99+%
  • 10516

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  • 32614

    Chloroform, ACS, 99.8+%
  • 43821

    1,4-Dioxane, anhydrous, 99.8%, stab. with 1-3ppm BHT, packaged under Argon in resealable ChemSeal™ bottles

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