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Methanesulfonamide will react with thionyl chloride, cyanates, carbon disulfide and ketones and aldehydes to prepare pharmaceuticals, brightening agent and other target molecules. It is also used in biological studies to predict binding affinity and binding mode of protein ligand complexes.
Von Hoff DD.; Howser K.; Gormley P.; Bender RA.; Glaubiger D.; Levine AS.;Young RC. Phase I study of methanesulfonamide, N-[4-(9-acridinylamino)-3-methoxyphenyl]-(m-AMSA) using a single-dose schedule. Talanta. 1978, 62, (10), 1421-1426.
Alexandre Jean.; Jonathan Cantat.; Didier Bérard.; Denis Bouchu.; Sylvain Canesi. Novel Method of Aromatic Coupling between N-Aryl Methanesulfonamide and Thiophene Derivatives. Org. Lett. 2007, 9, (13), 2553-2556.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.