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98-10-2 - Benzenesulfonamide, 98+% - A10891 - Alfa Aesar

A10891 Benzenesulfonamide, 98+%

CAS Number
98-10-2
Synonyms

Size Price ($) Quantity Availability
250g 35.43
1000g 88.83
5000g 305.60
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Benzenesulfonamide, 98+%

MDL
MFCD00007930
EINECS
202-637-1

Chemical Properties

Formula
C6H7NO2S
Formula Weight
157.19
Melting point
151-154°
Flash Point
250°(482°F)
Solubility
Soluble in methanol (25 mg/ml), and water (4.3 mg/ml at 16°C).

Applications

The presence of the benzenesulfonylamido (BS) groups shifted the activity of classic antimicrobial fluoroquinolones from being more active against Gram-negative to Gram-positive strains. Biospecific adsorption of carbonic anhydrase to self-assembled monolayers of alkanethiolates that present benzenesulfonamide groups on gold. Biospecific binding of carbonic anhydrase to mixed sams presenting benzenesulfonamide ligands led to a model system for studying lateral steric effects. In engineering the specificity of antibacterial fluoroquinolones, benzenesulfonamide modifications at c-7 of ciprofloxacin change its primary target instreptococcus pneumoniae from topoisomerase iv to gyrase. Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Milan Mrksich,; Jocelyn R. Grunwell,; George M. Whitesides .Biospecific Adsorption of Carbonic Anhydrase to Self-Assembled Monolayers of Alkanethiolates That Present Benzenesulfonamide Groups on Gold. J. Am. Chem. Soc., . 1995, 117 (48),12009-12010.

Joydeep Lahiri,; Lyle Isaacs,; Bartosz Grzybowski,; Jeffrey D. Carbeck,; George M. Whitesides. title . Langmuir. 1999, 15(21),7186-7198.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P280f

Wear protective clothing.

Other References

Beilstein
1100566
Harmonized Tariff Code
2935.00
TSCA
Yes
RTECS
DA9380000

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