Biospecific adsorption of carbonic anhydrase to self-assembled monolayers of alkanethiolates that present benzenesulfonamide groups on gold. Biospecific binding of carbonic anhydrase to mixed sams presenting benzenesulfonamide ligands led to a model system for studying lateral steric effects. Benzenesulfonamide modifications at c-7 of ciprofloxacin change its primary target instreptococcus pneumoniae from topoisomerase iv to gyrase. Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.
Milan Mrksich,; Jocelyn R. Grunwell,; George M. Whitesides .Biospecific Adsorption of Carbonic Anhydrase to Self-Assembled Monolayers of Alkanethiolates That Present Benzenesulfonamide Groups on Gold. J. Am. Chem. Soc., . 1995, 117 (48),12009-12010.
Joydeep Lahiri,; Lyle Isaacs,; Bartosz Grzybowski,; Jeffrey D. Carbeck,; George M. Whitesides. title . Langmuir. 1999, 15(21),7186-7198.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P280f
Wear protective clothing.