I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Ethyl L-lactate is used in the preparation of food additives, aryl aldimines, fragrances and in pharmaceutical preparations. It can be considered as a green solvent in chemical industries due to its biodegradable nature. As a solvent, it used in the production of nitrocellulose, cellulose acetate and cellulose ethers.
Ethyl (or isobutyl) L-lactate adds to aryl methyl ketenes to give esters of 2-arylpropionic acids in which the chirality is transferred to the new chiral center to a surprising degree: J. Am. Chem. Soc., 111, 7650 (1989):
Silylation followed by reaction with MeLi gives a useful chiral synthon. For preparation and discussion of reactivity, see: Org. Synth. Coll., 9, 139 (1998):
For reaction with Diphenylphosphonic azide, A12124, in the prepartaion, with inversion, of ethyl (R)-2-azidopropionate, see: Org. Synth., 75, 31 (1997).
Upare, P. P.; Lee, M.; Hwang, D. W.; Hwang, Y. K.; Chang, J. S. New heterogeneous Pb oxide catalysts for lactide production from an azeotropic mixture of ethyl lactate and water. Catal. Commun. 2014, 56, 179-183.
Williams, J. D.; Torhan, M. C.; Neelagiri, V. R.; Brown, C.; Bowlin, N. O.; Di, M.; Moir, D. T. Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS). Bioorg. Med. Chem. 2015, 23 (5), 1027-1043.
Hazard Statements: H226-H318-H335
Flammable liquid and vapour. Causes serious eye damage. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.