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A10919 2-Amino-6-fluorobenzoic acid, 98%

CAS Number
434-76-4
Synonyms
6-Fluoroanthranilic acid

Stock No. Size Price ($) Quantity Availability
A10919-03 1g 32.30
A10919-06 5g 113.00
A10919-14 25g 390.00
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2-Amino-6-fluorobenzoic acid, 98%

MDL
MFCD00067781
EINECS
000-000-0

Chemical Properties

Formula
C7H6FNO2
Formula Weight
155.13
Melting point
165-167°
Storage & Sensitivity
Ambient temperatures.

Applications

Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Y.S. Shina,; S.J. Song,; S.U. Kanga,; H.S. Hwanga,; J.W. Choid,; B.H. Lee,; Y.-S. Jung,; C.-H. Kim. A novel synthetic compound, 3-amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione, inhibits cisplatin-induced hearing loss by the suppression of reactive oxygen species: In vitro and in vivo study. Neuroscience. 2013, 232 1-12.

Jean-Michel Becht,; Cédric Catala,;Claude Le Drian,; Alain Wagner. Synthesis of Biaryls via Decarboxylative Pd-Catalyzed Cross-Coupling Reaction . Org Letter. 2007, 9 (9), 1781-1783.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3540926
Harmonized Tariff Code
2922.49
TSCA
No

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