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4-Bromo-1-butene is used in the preparation of 4-(3-butenyloxy)benzoic acid and largazole. It is also used in double alkylation of lactams followed by Grubbs ring-closing metathesis to yield gymnodimine. Further, it serves as a reagent in the preparation of dienehydrazides.
Hoyt, J. M.; Schmidt, V. A.; Tondreau, A. M.; Chirik, P. J. Iron-catalyzed intermolecular [2+2] cycloadditions of unactivated alkenes. Science 2015, 349 (6251), 960-963.
Liu, T.; Nie, Y.; Chen, R.; Zhang, L.; Meng, Y.; Li, X. Hyperbranched polyether as an all-purpose epoxy modifier: controlled synthesis and toughening mechanisms. J. Mater. Chem. A 2015, 3 (3), 1188-1198.
Hazard Statements: H225-H319-H334-H317-H335
Highly flammable liquid and vapour. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statements: P210-P284-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.