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Diethyl ethylphosphonate is used for heavy-metal extraction and solvent separation. It is also used as a gasoline additive, antifoam agent, plasticizer and textile conditioner. Further, it serves as an antistatic agent, flame retardant and as a general reagent in phosphinoalkene and phosphinoalkyne synthesis.
Reaction of the lithio-derivative with diethyl carbonate followed by Wadsworth-Emmons olefination (see Appendix 1) provides a route to ɑ-methylacrylic esters in high yield: Synth. Commun., 18, 1349 (1988):
Zhu, X.; Jiang, X.; Ai, X.; Yang, H.; Cao, Y. Bis(2,2,2-Trifluoroethyl) Ethylphosphonate as Novel High-efficient Flame Retardant Additive for Safer Lithium-ion Battery. Electrochim. Acta 2015, 165, 67-71.
Hubert, J. G.; Furkert, D. P.; Brimble, M. A. Preparation of cis-gamma-Hydroxycarvone Derivatives for Synthesis of Sesterterpenoid Natural Products: Total Synthesis of Phorbin A. J. Org. Chem. 2015, 80 (4), 2231-2239.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant