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Formamide is used for cryopreservation of tissues and organs and in hybridization buffers. It acts as an RNA stabiliser in gel electrophoresis by deionizing RNA. It is used as an alternative solvent for the electrostatic self-assembly of polymer nanofilms. It is used in the preparation of brain sections of mice for BrdU immunohistochemistry and fish analysis of HeLa cells. It essentially plays a vital role in crystallization of pharmaceuticals, in soil stabilization, as a solvent in inks, as a component of liquid fertilizers, as a heat-resistant coatings and in some personal care products.
An, H.; Liu, G.; Rob Atkin, R.; Craig, V. S. J. Surface Nanobubbles in Nonaqueous Media: Looking for Nanobubbles in DMSO, Formamide, Propylene Carbonate, Ethylammonium Nitrate, and Propylammonium Nitrate. ACS Nano 2015, 9 (7), 7596-7607.
Yang, Z.; Price, N. E.; Johnson, K. M.; Gates, K. S. Characterization of Interstrand DNA-DNA Cross-Links Derived from Abasic Sites Using Bacteriophage ?29 DNA Polymerase. Biochemistry 2015, 54 (27), 4259-4266.
Hazard Statements: H351-H360FD-H373
Suspected of causing cancer. May damage fertility. Suspected of damaging the unborn child. May damage fertility. May damage the unborn child. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P201-P202-P260-P281-P308+P313-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant