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76-03-9 - Trichloroacetic acid, 99% - TCA - A11156 - Alfa Aesar

A11156 Trichloroacetic acid, 99%

CAS Number
76-03-9
Synonyms
TCA

Size Price ($) Quantity Availability
250g 30.69
500g 51.91
1000g 89.82
5000g 366.68
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Trichloroacetic acid, 99%

MDL
MFCD00004177
EINECS
200-927-2

Chemical Properties

Formula
Cl3CCO2H
Formula Weight
163.39
Melting point
54-58°
Boiling Point
196°
Density
1.629
Sensitivity
Hygroscopic
Solubility
Soluble in water, alcohol, ethyl ether, benzene, acetone, o-xylene and carbon tetrachloride.

Applications

Protein precipitation reagent Trichloroacetic acid is used as a precipitating agent in biochemistry for precipitation of proteins, DNA and RNA. It is an active ingredient used for cosmetic treatments like chemical peels, tattoo removal and the treatment of warts including genital warts. It is also used to determine protein concentration and a decalcifier and fixative in microscopy.

Notes

Moisture sensitive. Hygroscopic. Store in cool place. Incompatible with strong oxidizing agents, strong bases and amines.

Literature References

Trihaloacetic acids react with aldehydes in DMSO at room temperature to give trihalomethyl carbinols: J. Chem. Soc., Perkin 2, 1247 (1984):

The acid and its Na salt (1:1) in DMF are also effective: Tetrahedron Lett., 33, 3435 (1992). Use of HMPA or DMI extends the scope to less reactive aldehydes: Synthesis, 327 (1990).

Malachová, A.; Štočková, L.; Wakker, A.; Varga, E.; Krska, R.; Michlmayr, H.; Adam, G.; Berthiller, F. Critical evaluation of indirect methods for the determination of deoxynivalenol and its conjugated forms in cereals. Anal. Bioanal. Chem. 2015, 407 (20), 6009-6020.

Young, M. S.; van Tran, K.; Goh, E.; Shia, J. C. A Rapid SPE-Based Analytical Method for UPLC/MS/MS Determination of Aminoglycoside Antibiotic Residues in Bovine Milk, Muscle, and Kidney. J. AOAC Int. 2014, 97 (6), 1737-1741.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H400-H410

Causes severe skin burns and eye damage. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects.

Precautionary Statements: P260-P273-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9627
Beilstein
970119
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.40
TSCA
Yes
RTECS
AJ7875000

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