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Formamidine acetate is used as an intermediate in the synthesis of active pharmaceutical ingredients. It is also used as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.
More convenient source of formamidine than the corresponding chloride in that it is non-hygroscopic and, being the salt of a weaker acid, can often be used in synthesis without the need to liberate the free base.
Widely used in heterocyclic syntheses, for example of pyrimidine and imidazole derivatives.
Maiden, T. M. M.; Swanson, S.; Procopiou, P. A.; Harrity, J. P. A Mild and Regioselective Route to Functionalized Quinazolines. Chem. Eur. J. 2015, 21 (41), 14342-14346.
Cebrián, C.; Natali, M.; Villa, D.; Panigati, M.; Mauro, M.; D'Alfonso, G.; De Cola, L. Luminescent supramolecular soft nanostructures from amphiphilic dinuclear Re(I) complexes. Nanoscale 2015, 7, 12000-12009.
Hazard Statements: H315-H317-H319-H335
Causes skin irritation. May cause an allergic skin reaction. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P312-P333+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant