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Formamidine acetate is used as an intermediate in the synthesis of active pharmaceutical ingredients. It is also used as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.
More convenient source of formamidine than the corresponding chloride in that it is non-hygroscopic and, being the salt of a weaker acid, can often be used in synthesis without the need to liberate the free base.
Widely used in heterocyclic syntheses, for example of pyrimidine and imidazole derivatives.
Maiden, T. M. M.; Swanson, S.; Procopiou, P. A.; Harrity, J. P. A Mild and Regioselective Route to Functionalized Quinazolines. Chem. Eur. J. 2015, 21 (41), 14342-14346.
Cebrián, C.; Natali, M.; Villa, D.; Panigati, M.; Mauro, M.; D'Alfonso, G.; De Cola, L. Luminescent supramolecular soft nanostructures from amphiphilic dinuclear Re(I) complexes. Nanoscale 2015, 7, 12000-12009.
Hazard Statements: H317
May cause an allergic skin reaction.
Precautionary Statements: P262-P280g
Do not get in eyes, on skin, or on clothing. Wear protective gloves.