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3473-63-0 - Formamidine acetate, 99% - A11158 - Alfa Aesar

A11158 Formamidine acetate, 99%

CAS Number
3473-63-0
Synonyms

Size Price ($) Quantity Availability
100g 44.81
500g 147.60
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Formamidine acetate, 99%

MDL
MFCD00012866
EINECS
222-442-5

Chemical Properties

Formula
C3H8N2O2
Formula Weight
104.11
Melting point
ca 158° dec.
Density
1.124
Sensitivity
Hygroscopic
Solubility
Soluble in water and hot alcohol.

Applications

Formamidine acetate is used as an intermediate in the synthesis of active pharmaceutical ingredients. It is also used as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.

Notes

Hygroscopic. Moisture sensitive. Incompatible with oxidizing agents.

Literature References

More convenient source of formamidine than the corresponding chloride in that it is non-hygroscopic and, being the salt of a weaker acid, can often be used in synthesis without the need to liberate the free base.

Widely used in heterocyclic syntheses, for example of pyrimidine and imidazole derivatives.

Maiden, T. M. M.; Swanson, S.; Procopiou, P. A.; Harrity, J. P. A Mild and Regioselective Route to Functionalized Quinazolines. Chem. Eur. J. 2015, 21 (41), 14342-14346.

Cebrián, C.; Natali, M.; Villa, D.; Panigati, M.; Mauro, M.; D'Alfonso, G.; De Cola, L. Luminescent supramolecular soft nanostructures from amphiphilic dinuclear Re(I) complexes. Nanoscale 2015, 7, 12000-12009.

GHS Hazard and Precautionary Statements

Hazard Statements: H317

May cause an allergic skin reaction.

Precautionary Statements: P262-P280g

Do not get in eyes, on skin, or on clothing. Wear protective gloves.

Other References

Beilstein
3563488
Harmonized Tariff Code
2925.29
TSCA
Yes

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