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2,6-Dichloropyrazine is used in the preparation of pyrazine and pyridine compounds as ATR kinase inhibitors. It is also used in the synthesis of oxacalixarenes containing nitrogen heterocycles.
Zhao, M.; Li, P.; Xie, X.; Su, J.; Zheng, W. Synthesis and structural characterization of 2,6-bis(1,2,4-diazaphospholyl-1-yl)pyridine zinc and 2,6-bis(1,2,4-diazaphospholyl-1-yl)pyrazine copper complexes. Polyhedron 2015, 85, 302-311.
Tominaga, M.; Kunitomi, N.; Katagiri, K.; Itoh, T. Adamantane-Based Oxacyclophanes Containing Pyrazines: Synthesis, Crystal Structure, and Self-Assembly Behavior. Org. Lett. 2015, 17 (4), 786-789.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant