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Denatures and solubilizes proteins for electrophoresis.Sodium n-dodecyl sulfate is an anionic detergent used to function as a protein denaturant. It is mainly used in detergents for laundry with many cleaning applications. It finds application in the determination of protein molecular weight by polyacrylamide gel electrophoresis and in the analysis of hemoglobin. In food products, it is used as an emulsifying agent and a whipping aid. It is widely found in toothpastes, shampoos, shaving creams and bubble bath formulations due to its thickening effect and ability to create a lather.
The reaction rate and endo:exo ratio in the Diels-Alder cycloadditions of acrylic acid derivatives to cyclopentadiene is increased in the presence of this surfactant: Tetrahedron Lett., 27, 1285 (1986)._x000D_
Chen, J.; Gong, X.; Yang, H.; Yao, Y.; Xu, M.; Chen, Q.; Cheng, R. NMR study on the effects of sodium n-dodecyl sulfate on the coil-to-globule transition of poly (N-isopropylacrylamide) in aqueous solutions. Macromolecules 2011, 44 (15), 6227-6231.
Nwamba, C. O.; Chilaka, F. C.; Movahedi, A. A. M. Cation Modulation of Hemoglobin Interaction with Sodium n-Dodecyl Sulfate (SDS). III: Calcium Interaction with R-and Mixed Spin States of Hemoglobin S at pH 5.0: The Musical Chair Paradox. Cell Biochem. Biophys. 2013, 67, (2), 547-555.
Hazard Statements: H228-H302-H315-H318-H332-H335-H500
Flammable solid. Harmful if swallowed. Causes skin irritation. Causes serious eye damage. Harmful if inhaled. May cause respiratory irritation. May form combustible dust concentrations in air
Precautionary Statements: P210-P240-P241-P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant