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Denatures and solubilizes proteins for electrophoresis.Sodium n-dodecyl sulfate is an anionic detergent used to function as a protein denaturant. It is mainly used in detergents for laundry with many cleaning applications. It finds application in the determination of protein molecular weight by polyacrylamide gel electrophoresis and in the analysis of hemoglobin. In food products, it is used as an emulsifying agent and a whipping aid. It is widely found in toothpastes, shampoos, shaving creams and bubble bath formulations due to its thickening effect and ability to create a lather.
The reaction rate and endo:exo ratio in the Diels-Alder cycloadditions of acrylic acid derivatives to cyclopentadiene is increased in the presence of this surfactant: Tetrahedron Lett., 27, 1285 (1986)._x000D_
Chen, J.; Gong, X.; Yang, H.; Yao, Y.; Xu, M.; Chen, Q.; Cheng, R. NMR study on the effects of sodium n-dodecyl sulfate on the coil-to-globule transition of poly (N-isopropylacrylamide) in aqueous solutions. Macromolecules 2011, 44 (15), 6227-6231.
Nwamba, C. O.; Chilaka, F. C.; Movahedi, A. A. M. Cation Modulation of Hemoglobin Interaction with Sodium n-Dodecyl Sulfate (SDS). III: Calcium Interaction with R-and Mixed Spin States of Hemoglobin S at pH 5.0: The Musical Chair Paradox. Cell Biochem. Biophys. 2013, 67, (2), 547-555.
Hazard Statements: H228-H302-H311-H315-H319-H335
Flammable solid. Harmful if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P280-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.