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454-31-9 - Ethyl difluoroacetate, 98% - Difluoroacetic acid ethyl ester - A11215 - Alfa Aesar

A11215 Ethyl difluoroacetate, 98%

CAS Number
454-31-9
Synonyms
Difluoroacetic acid ethyl ester

Size Price ($) Quantity Availability
5g 72.09
25g 214.26
100g 675.43
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Ethyl difluoroacetate, 98%

MDL
MFCD00013578
EINECS
207-223-4

Chemical Properties

Formula
F2CHCO2CH2CH3
Formula Weight
124.09
Boiling Point
98-99°
Flash Point
25°(77°F)
Density
1.242
Refractive Index
1.3475
Solubility
Slightly soluble in water

Applications

Ethyl difluoroacetate is used in pharmaceutical intermediates, acrylization oxidation and halogenating reaction of catalyst. Also ethyl difluoroacetate is used in preparing pyrrazolo-pyrimidine derivatives.

Notes

Hygroscopic. Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

William P. Jencks.; Joan Carriuolo. General Base Catalysis of Ester Hydrolysis1. J. Am. Chem. Soc. 1961, 83, (7), 1743-1750.

Myron L. Bender.; Edward J. Pollock.; Maurice C. Neveu. Deuterium Oxide Solvent Isotope Effects in the Nucleophilic Reactions of Phenyl Esters. J. Am. Chem. Soc. 1962, 84, (4), 595-599.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H226

Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1748597
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2915.90
TSCA
Yes

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