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A11215 Ethyl difluoroacetate, 98%

CAS Number
454-31-9
Synonyms
Difluoroacetic acid ethyl ester

Stock No. Size Price ($) Quantity Availability
A11215-06 5g 68.30
A11215-14 25g 227.00
A11215-22 100g 670.00
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Ethyl difluoroacetate, 98%

MDL
MFCD00013578
EINECS
207-223-4

Chemical Properties

Formula
F2CHCO2CH2CH3
Formula Weight
124.09
Boiling Point
98-99°
Flash Point
25°(77°F)
Density
1.242
Refractive Index
1.3475
Storage & Sensitivity
Ambient temperatures.
Solubility
Slightly soluble in water

Applications

Ethyl difluoroacetate is used in pharmaceutical intermediates, acrylization oxidation and halogenating reaction of catalyst. Also ethyl difluoroacetate is used in preparing pyrrazolo-pyrimidine derivatives.

Notes

Hygroscopic. Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

William P. Jencks.; Joan Carriuolo. General Base Catalysis of Ester Hydrolysis1. J. Am. Chem. Soc. 1961, 83, (7), 1743-1750.

Myron L. Bender.; Edward J. Pollock.; Maurice C. Neveu. Deuterium Oxide Solvent Isotope Effects in the Nucleophilic Reactions of Phenyl Esters. J. Am. Chem. Soc. 1962, 84, (4), 595-599.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H314

Flammable liquid and vapour. Causes severe skin burns and eye damage.

Precautionary Statements: P210-P233-P240-P241-P242-P243-P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1748597
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2915.90
TSCA
Yes

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