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2-Methylcyclohexane-1,3-dione acts as a synthetic intermediate. It is an important starting material, exemplified in a formal synthesis of acorone. It is also used in Organic Synthesis, Pharmaceuticals, Agrochemicals.
Tetsuji Yanami; Michiharu Kato; Masaaki Miyashita; Akira Yoshikoshi, Yasuhiro Itagaki; Kenji Matsuura. Oxygen transfer reaction in acetonylation of 2-methylcyclohexane-1,3-dione with 2-nitropropene. J. Org. Chem. 1977, 42, (16), 2779-2781.
Useful building block for ring B of the steroid nucleus: J. Am. Chem. Soc., 79, 5542 (1957); J. Chem. Soc., 3441 (1957); Helv. Chim. Acta, 36, 482 (1953). For C-methylation using MeI and Benzyltrimethylammonium hydroxide, A14927, see: Org. Synth. Coll., 8, 312 (1993).
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant