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30525-89-4 - Paraformaldehyde, 97% - Polyoxymethylene - A11313 - Alfa Aesar

A11313 Paraformaldehyde, 97%

CAS Number
30525-89-4
Synonyms
Polyoxymethylene

Size Price ($) Quantity Availability
100g 19.62
500g 20.61
2500g 59.27
10000g 185.40
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Paraformaldehyde, 97%

MDL
MFCD00133991
EINECS
200-001-8

Chemical Properties

Formula
(CH2O)n
Melting point
120-170° dec.
Flash Point
71°(159°F)
Density
1.30
Solubility
Soluble in hot water. Insoluble in water, ether and alcohol.

Applications

Paraformaldehyde is used as a fumigant, a disinfectant and in the manufacture of synthetic resins like melamine resin, phenol resin and polyacetal resin. It is also used in cell culture. It also serves as a fixative in electron microscopy. It is also used in the preparation of formalin fixatives for tissues or cells.

Notes

Store in cool place. Incompatible with brass, steel, copper, acid anhydrides, strong oxidizing agents and strong reducing agents.

Literature References

Formaldehyde monomer, generated by thermolysis, has been used for the ɑ-hydroxymethylation of dilithiated carboxylic acids. Dehydration of the products affords ɑ-alkyl acrylic acids: J. Org. Chem., 37, 1256 (1972). Monomeric formaldehyde can also be prepared as a THF solution by dehydration with p-Toluenesulfonic anhydride, L00160, and co-distillation of the monomer with the solvent: Synlett, 704 (1990). The use of anhydrous molecular formaldehyde for hydroxymethylation reactions has been discussed: Synlett, 227 (1990).

For use in the preparation of di-t-butyl methylenemalonate, see Di-tert-butyl­ malonate, A12774. For the direct ɑ-methylenation of ketones, see N-Methyl­anilinium trifluoroacetate, A17781.

For use in preparation of Mannich bases, see: Org. Synth. Coll., 3, 305 (1955); 4, 281 (1963). For reviews, see: Org. React., 1, 303 (1942); Synthesis, 703 (1973); Tetrahedron, 46, 1791 (1990).

In the presence of HCl, aromatics undergo chloromethylation. For reviews, see: Org. React., 1, 63 (1942); Russ. Chem. Rev., 46, 891 (1977). Caution! carcinogenic bis(chloromethyl) ether is formed in these reactions. In combination with Hydrobromic acid, A14475, the bromomethylation of aromatics has been effected: J. Org. Chem., 58, 1262 (1993). The same combination also N-bromomethylates phthalimide and other imides: Synlett, 933 (1994).

Reaction with dialkyl phosphites gives hydroxymethyl phosphonates, which, after O-protection, undergo the Horner-Wadsworth-Emmons reaction to give enol ethers. See, e.g.: Org. Synth. Coll., 7, 160 (1990).

See also Formaldehyde, A16163 and 1,3,5-Trioxane, A15639 .

Suenobu, T.; Isaka, Y.; Shibata, S.; Fukuzumi, S. Catalytic hydrogen production from paraformaldehyde and water using an organoiridium complex. Chem. Commun. 2015, 51 (9), 1670-1672.

Fuentes, J. A.; Pittaway, R.; Clarke, M. L. Rapid Asymmetric Transfer Hydroformylation (ATHF) of Disubstituted Alkenes Using Paraformaldehyde as a Syngas Surrogate. Chem. Eur. J. 2015, 21 (30), 10645-10649.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H228-H351-H302-H332-H317

Causes severe skin burns and eye damage. Causes serious eye damage. Flammable solid. Suspected of causing cancer. Harmful if swallowed. Harmful if inhaled. May cause an allergic skin reaction.

Precautionary Statements: P210-P260-P201-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7025
Beilstein
102769
Hazard Class
4.1
Packing Group
III
Harmonized Tariff Code
2912.60
TSCA
Yes
RTECS
RV0540000

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