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725-89-3 - 3,5-Bis(trifluoromethyl)benzoic acid, 98% - A11325 - Alfa Aesar

A11325 3,5-Bis(trifluoromethyl)benzoic acid, 98%

CAS Number
725-89-3
Synonyms

Size Price ($) Quantity Availability
5g 40.88
25g 153.77
100g 407.30
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3,5-Bis(trifluoromethyl)benzoic acid, 98%

MDL
MFCD00000388
EINECS
211-970-1

Chemical Properties

Formula
C9H4F6O2
Formula Weight
258.12
Melting point
140-144°
Density
1.420
Solubility
Slightly soluble in water.

Applications

In vitro metabolism studies on a series of 3,5-bis(trifluoromethyl)benzyl ethers have identified 3,5-bis(trifluoromethyl)benzoic acid as a significant metabolite possibly arising via oxidation of the benzylic position. The reactivity of the hydroxy- propyl units was demonstrated by the esterification of por- phyrazine derivatives with 3,5-bis(trifluoromethyl)benzoic acid in the presence of dicyclohexylcarbodiimide and toluene- p-sulfonic acid.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Swain CJ, et al. 3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution.. Bioorg. Med. Chem.Lett. 1997, 7(23), 2959-62.

Tuğba Şimşek,; Ergün Gonca. Enrichment of solubility by esterification: Metal-free and metallo-porphyrazines with polyfluorinated units. Transition Metal Chemistry. 2013, 38(1), 37-43.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2058600
Harmonized Tariff Code
2916.39
TSCA
No
RTECS
DG4448020

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