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A11330 2-Amino-4,6-dichloropyrimidine, 98%

CAS Number
56-05-3
Synonyms
4,6-Dichloro-2-pyrimidinamine

Stock No. Size Price ($) Quantity Availability
A11330-06 5g 44.60
A11330-14 25g 142.00
A11330-22 100g 445.00
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2-Amino-4,6-dichloropyrimidine, 98%

MDL
MFCD00006090
EINECS
200-253-9

Chemical Properties

Formula
C4H3Cl2N3
Formula Weight
164.00
Melting point
218-222°
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water, soluble in acetone, two monomer (VCM) and thermal toluene.

Applications

Microwave-assisted synthesis of pyrazolo [3, 4-d] pyrimidines from 2-amino-4, 6-dichloropyrimidine-5-carbaldehyde is under solvent-free conditions. A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh3)2Cl2 as catalyst.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Dana Hocková,; Antonı?n Holý,; Milena Masojı?dková,; Ivan Votruba. An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine. Tetrahedron. 2004, 60 (23), 4983-4987.

C. J. B. Clews,; W. Cochran. The structures of pyrimidines and purines. I. A determination of the structures of 2-amino-4-methyl-6-chloropyrimidine and 2-amino-4,6-dichloropyrimidine by X-ray methods . Acta Cryst.. 1948, 14-11.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
118454
Harmonized Tariff Code
2933.59
TSCA
Yes
RTECS
UV6260485

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