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2766-74-7 - 5-Chlorothiophene-2-sulfonyl chloride, 97% - A11348 - Alfa Aesar

A11348 5-Chlorothiophene-2-sulfonyl chloride, 97%

CAS Number
2766-74-7
Synonyms

Size Price ($) Quantity Availability
1g 40.17
5g 111.60
10g 226.60
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5-Chlorothiophene-2-sulfonyl chloride, 97%

MDL
MFCD00051667
EINECS
700-248-6

Chemical Properties

Formula
C4H2Cl2O2S2
Formula Weight
217.09
Boiling Point
117-120°/14mm
Flash Point
>110°(230°F)
Density
1.623
Refractive Index
1.5860
Sensitivity
Moisture Sensitive
Solubility
Not miscible in water.

Applications

5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.

Notes

Moisture Sensitive. Store at 4°C. Incomaptible with oxidizing agents and bases.

Literature References

Varun Rawat; Pandurang V. Chouthaiwale; Vilas B. Chavan; Gurunath Suryavanshi; Arumugam Sudalai. A facile enantioselective synthesis of (S)-N-(5-chlorothiophene-2-sulfonyl)-β,β-diethylalaninol via proline-catalyzed asymmetric α-aminooxylation and α-amination of aldehyde.Tetrahedron Letters.2010, 51, 6565-6567.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
130710
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2934.99
TSCA
No

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