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A11379 Tris(hydroxymethyl)aminomethane hydrochloride, 99+%

CAS Number
2-Amino-2-hydroxymethyl-1,3-propanediol hydrochloride
TRIS hydrochloride

Stock No. Size Price ($) Quantity Availability
A11379-18 50g 25.70
A11379-30 250g 65.40
A11379-0B 1000g 187.00
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Tris(hydroxymethyl)aminomethane hydrochloride, 99+%


Chemical Properties

Formula Weight
Melting point
ca 152° dec.
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Soluble in water.


Tris(hydroxymethyl)aminomethane hydrochloride is used as a component of buffer solutions in biology, biochemistry and molecular biology. It is also used for crystallization of proteins at various pH values. Further, it inhibits motor responses to adrenergic motor nerve stimulation in smooth muscles. In addition to this, it is used in coelomic fluid and in cortland medium to store unfertilized rainbow trout eggs.


Hygroscopic. Incompatible with strong oxidizing agents, strong acids and bases.

Literature References

Biological buffer.

Lin, L.; Pan, Q. ZnFe2O4@ C/graphene nanocomposites as excellent anode materials for lithium batteries. J. Mater. Chem. A 2015, 3 (4), 1724-1729.

Oishi, M. Enzyme-free and isothermal detection of microRNA based on click-chemical ligation-assisted hybridization coupled with hybridization chain reaction signal amplification. Anal. Bioanal. Chem. 2015, 407 (14), 4165-4172.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • A10870

    2,3,5-Triphenyl-2H-tetrazolium chloride, 98%
  • A16104

    MES monohydrate, 98%
  • A18494

    Tris(hydroxymethyl)aminomethane, 99%
  • 12314

    Sodium chloride, ACS, 99.0% min
  • 31801

    Tris(hydroxymethyl)aminomethane, ACS, 99.8-100.1% (Assay, dried basis)

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